Description

5-(Thiophen-2-Yl)-(1,3)Dioxolo(4,5-D)Pyrimidine-7-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, serving as a critical building block for novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Heterocyclic Compound Synthesis: Serves as a versatile building block for constructing complex polycyclic frameworks containing thiophene and pyrimidine moieties.
• Active Pharmaceutical Ingredient (API) Development: Integral in the development and scale-up processes for new APIs requiring this specific carboxylic acid derivative.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the global pharmaceutical industry.

Basic Information

Product Name	5-(Thiophen-2-Yl)-(1,3)Dioxolo(4,5-D)Pyrimidine-7-Carboxylic Acid
CAS No.	766557-57-7
Molecular Formula	C12H6N2O4S
Molecular Weight	274.25 g/mol
Synonyms	5-(Thiophen-2-yl)[1,3]dioxolo[4,5-d]pyrimidine-7-carboxylic acid; 5-(2-Thienyl)-1,3-dioxolo[4,5-d]pyrimidine-7-carboxylic Acid; 7-Carboxy-5-(2-thienyl)-1,3-dioxolo[4,5-d]pyrimidine; Thienyl-dioxolopyrimidinecarboxylic acid; 766557-57-7; 5-(Thiophen-2-yl)-1,3-dioxolo[4,5-d]pyrimidine-7-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-(Thiophen-2-Yl)-(1,3)Dioxolo(4,5-D)Pyrimidine-7-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are manufactured and tested in facilities that implement cGMP (current Good Manufacturing Practice) principles where applicable. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.