Description

4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydropyridopyrimidine class of heterocyclic compounds. Its core value lies in serving as a critical building block for the synthesis of novel, biologically active molecules, particularly in medicinal chemistry and drug discovery. This compound is primarily needed by research institutions and pharmaceutical companies engaged in developing new therapeutic agents, especially those targeting kinase inhibition and other enzyme-related pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, particularly for oncology and central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Kinase Inhibitor Development: The pyrimidine core structure makes it a valuable fragment for designing and optimizing novel kinase inhibitors.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes to study specific biological targets and pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
CAS No.	763925-38-8
Molecular Formula	C9H7ClF3N3
Molecular Weight	249.62 g/mol
Synonyms	4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 5,6,7,8-Tetrahydro-4-chloro-2-(trifluoromethyl)pyrido[3,4-d]pyrimidine; 763925-38-8; 4-Chloro-2-trifluoromethyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; Pyrido[3,4-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-2-(trifluoromethyl)-; 4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.