Description

Pyr-Val-Lys-Leu-Tyr-Arg-Pro-Nh2 Hcl is a synthetic heptapeptide sequence modified with a pyroglutamyl group at the N-terminus and an amidated C-terminus. This compound is of significant interest in biochemical and pharmaceutical research, particularly for studying protease interactions and as a potential precursor in peptide-based drug discovery. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical developers engaged in proteomics, enzymology, and therapeutic peptide development.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in enzymatic assays to study the activity and kinetics of proteases like kallikreins or other serine proteases.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of novel peptide-based therapeutics targeting cardiovascular, inflammatory, or metabolic pathways.
• Proteomics & Diagnostics: Employed in the development of diagnostic kits and assays for detecting specific enzyme activities related to disease biomarkers.
• Academic Studies: Utilized in university and institutional labs for fundamental research on peptide structure-activity relationships (SAR) and signal transduction mechanisms.
• Peptide Library Synthesis: Acts as a building block or a template compound in the construction of focused peptide libraries for high-throughput screening.

Basic Information

Item	Details
Product Name	Pyr-Val-Lys-Leu-Tyr-Arg-Pro-Nh2 Hcl
CAS No.	763074-36-8
Molecular Formula	C44H70N12O10 • xHCl
Molecular Weight	~951.1 g/mol (free base)
Synonyms	Pyroglutamyl-Valyl-Lysyl-Leucyl-Tyrosyl-Arginyl-Prolinamide Hydrochloride; pGlu-Val-Lys-Leu-Tyr-Arg-Pro-NH2 • HCl; H-pGlu-Val-Lys-Leu-Tyr-Arg-Pro-NH2 • HCl; Kallidinogenase Substrate Analog; Bradykinin Potentiating Peptide Fragment; BPP Fragment; Heptapeptide pGlu-V-K-L-Y-R-P-NH2 HCl
EINECS	Contact for details

Quality Control

Every batch of Pyr-Val-Lys-Leu-Tyr-Arg-Pro-Nh2 Hcl is manufactured under strict quality management systems. We provide comprehensive analytical documentation to support your research and development needs. Certificates of Analysis (COA) are supplied with each shipment, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Assay (Content)	≥ 97.0% (on anhydrous basis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.