Description

4-Pyrimidinamine, 2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a key building block for novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) focused on developing new small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug discovery.
• Medicinal Chemistry Research: Serves as a crucial building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Used in organic synthesis to introduce the dichloropyrimidinamine moiety into more complex molecular architectures.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Agrochemical Research: Potential application as an intermediate in the development of novel crop protection agents and pesticides.
• Academic & Institutional Research: Used in university and institutional labs for fundamental chemical research and the development of new synthetic methodologies.

Basic Information

Product Name	4-Pyrimidinamine, 2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
CAS No.	761440-16-8
Molecular Formula	C13H13Cl2N3O2S
Molecular Weight	346.23 g/mol
Synonyms	2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine; 2,5-Dichloro-N-(2-isopropylsulfonylphenyl)pyrimidin-4-amine; N-(2-((Isopropyl)sulfonyl)phenyl)-2,5-dichloro-4-pyrimidinamine; 761440-16-8; 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-; 2,5-Dichloro-N-(2-(propan-2-ylsulfonyl)phenyl)pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinamine, 2,5-Dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with complete batch traceability are provided to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids/bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.