Description

Benzenesulfonamide, 2-[(5-Bromo-2-Chloro-4-Pyrimidinyl)Amino]-n-Methyl- CAS NO 761440-01-1 is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated pyrimidine and benzenesulfonamide structure. This compound is of significant value for research and development in medicinal chemistry, serving as a critical building block for synthesizing novel therapeutic agents. It is primarily sought by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of new drug candidates, particularly in oncology and targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates for targeted therapies.
• Kinase Inhibitor Research: Used in the development and optimization of potent kinase inhibitors due to its pyrimidine scaffold.
• Medicinal Chemistry R&D: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead compound optimization.
• Oncology Drug Discovery: Employed in the research pathways for creating potential anti-cancer agents.
• Chemical Biology Probes: Utilized in the design of chemical probes to study specific biological pathways and protein functions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions.

Basic Information

Product Name	Benzenesulfonamide, 2-[(5-Bromo-2-Chloro-4-Pyrimidinyl)Amino]-n-Methyl- CAS NO 761440-01-1
CAS No.	761440-01-1
Molecular Formula	C11H10BrClN4O2S
Molecular Weight	377.64 g/mol
Synonyms	N-Methyl-2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]benzenesulfonamide; 2-[(5-Bromo-2-chloro-4-pyrimidinyl)amino]-N-methylbenzenesulfonamide; 761440-01-1; 5-Bromo-2-chloro-N-(2-(methylsulfamoyl)phenyl)pyrimidin-4-amine; Benzenesulfonamide, 2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]-N-methyl-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for pharmaceutical R&D. Certificates of Analysis (COA) are provided with each shipment, detailing purity, identity, and impurity profiles. Quality is verified through modern analytical techniques including HPLC, NMR, and mass spectrometry. We operate under a quality management system and can support development projects requiring materials manufactured under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.