Description

4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(Piperidin-3-Yloxy)-7-Methoxy-Quinazoline is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly kinase inhibitors.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted oncology drugs and kinase inhibitors.
• Biochemical Research: Used as a reference standard or active compound in pharmacological and enzyme inhibition studies.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry programs aiming to develop new therapeutic entities.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final chemical structure of potent active ingredients during GMP manufacturing processes.

Basic Information

Product Name	4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(Piperidin-3-Yloxy)-7-Methoxy-Quinazoline
CAS No.	760171-44-6
Molecular Formula	C20H20ClFN4O2
Molecular Weight	402.85 g/mol
Synonyms	4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-piperidinyl)oxy]-7-methoxyquinazoline; 6-(Piperidin-3-yloxy)-7-methoxy-4-[(3-chloro-4-fluorophenyl)amino]quinazoline; 760171-44-6; UNII-9K5J6QMF0F; 9K5J6QMF0F; BDBM50111057; CHEMBL3185148; CTK8C0665; AKOS040757393; DB08274
EINECS	Contact for details

Quality Control

Our 4-[(3-Chloro-4-Fluoro-Phenyl)Amino]-6-(Piperidin-3-Yloxy)-7-Methoxy-Quinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D and pre-clinical development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.