Description

Histidine, -α--Hydroxy- (9Ci) is a modified amino acid derivative, specifically a hydroxylated form of the essential amino acid L-histidine. This compound is significant for its role as a key chiral building block and intermediate in advanced pharmaceutical synthesis and biochemical research. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of complex drug molecules, particularly peptidomimetics and enzyme inhibitors.
• Biochemical Research: Used as a substrate or precursor in enzymatic studies and metabolic pathway investigations.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis to introduce modified histidine residues, altering peptide stability and function.
• Nutritional Science Studies: Utilized in research to study the metabolism and physiological effects of hydroxylated amino acid derivatives.
• Cosmetic Ingredient Development: Investigated for potential use in advanced skincare formulations due to its modified amino acid structure.
• Asymmetric Catalysis: Can be used as a ligand precursor or chiral auxiliary in asymmetric synthetic transformations.

Basic Information

Product Name	Histidine, -α--Hydroxy- (9Ci)
CAS No.	757243-24-6
Molecular Formula	C₆H₁₁N₃O₃
Molecular Weight	173.17 g/mol
Synonyms	α-Hydroxyhistidine; 2-Amino-3-(1H-imidazol-4-yl)-2-hydroxypropanoic acid; Hydroxyhistidine; (2S)-2-Amino-3-(1H-imidazol-5-yl)-2-hydroxypropanoic acid; L-α-Hydroxyhistidine; 2-Hydroxyhistidine; (S)-2-Hydroxy-3-(1H-imidazol-4-yl)propanoic acid; 3-(1H-Imidazol-4-yl)-2-hydroxyalanine
EINECS	Contact for details

Quality Control

Our Histidine, -α--Hydroxy- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.