Description

Cyclo (Arg-Gly-Asp-D-Phe-Glu) is a synthetic, cyclic pentapeptide containing the Arg-Gly-Asp (RGD) motif. This compound is a critical research tool for studying integrin-mediated cell adhesion, signaling, and migration processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on oncology, cardiovascular disease, and tissue engineering. The high-purity peptide is essential for reliable and reproducible experimental results in biochemical and cell-based assays.

Application

• Integrin Research: Used as a standard antagonist to study αvβ3, αvβ5, and other RGD-dependent integrins in competitive binding assays.
• Angiogenesis Studies: Applied in vitro and in vivo to inhibit neovascularization for cancer and ophthalmology research.
• Cell Adhesion & Migration Assays: Serves as a blocking agent to investigate tumor cell metastasis, platelet aggregation, and leukocyte extravasation.
• Biomaterial Functionalization: Used to coat surfaces (e.g., polymers, glass) to promote or control specific cell attachment in tissue engineering.
• Drug Discovery Screening: Acts as a reference compound in high-throughput screening for novel anti-thrombotic or anti-cancer therapeutics.
• Biochemical Pathway Analysis: Employed to elucidate downstream signaling cascades triggered by integrin-ligand interactions.

Basic Information

Product Name	Cyclo (Arg-Gly-Asp-D-Phe-Glu)
CAS No.	756500-22-8
Molecular Formula	C27H38N10O9
Molecular Weight	646.66 g/mol
Synonyms	c(RGDfE); Cyclo(Arg-Gly-Asp-D-Phe-Glu); Cyclo(RGD-D-Phe-Glu); cRGDfE peptide; RGD Cyclic Pentapeptide; Cyclo(-Arg-Gly-Asp-D-Phe-Glu-); Integrin αvβ3 antagonist (cyclic RGDfE); Cyclo(Arg-Gly-Asp-D-phenylalanine-Glutamic acid)
EINECS	Contact for details

Quality Control

Our Cyclo (Arg-Gly-Asp-D-Phe-Glu) is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Conforms
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.