Description

L-Norleucine, 3-Hydroxy-2-Methyl-, (3S)- (9Ci) is a non-proteinogenic amino acid derivative characterized by its specific stereochemistry and functional groups. This compound is a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for metabolic and neurological targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified amino acid residues, altering peptide stability, bioavailability, or activity.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and metabolic pathway research due to its structural similarity to natural amino acids.
• Ligand and Catalyst Development: Employed in the design and synthesis of chiral ligands for asymmetric catalysis and metal complexes.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Details
Product Name	L-Norleucine, 3-Hydroxy-2-Methyl-, (3S)- (9Ci)
CAS No.	755742-08-6
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	(2S,3S)-3-Hydroxy-2-methylnorleucine; (3S)-3-Hydroxy-2-methyl-L-norleucine; L-3-Hydroxy-2-methylnorleucine; (2S,3S)-2-Amino-3-hydroxy-2-methylhexanoic acid; 2-Methyl-3-hydroxynorleucine; (S,S)-Hmn; A non-proteinogenic amino acid derivative
EINECS	Contact for details

Quality Control

Our L-Norleucine, 3-Hydroxy-2-Methyl-, (3S)- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) documenting identity, purity, and specific tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.