Description

Butanoic Acid, 2-[(2-Chloro-5-Nitro-4-Pyrimidinyl)Cyclopentylamino]-, Methyl Ester, (2R)- is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a pyrimidine core with chloro and nitro substituents, makes it a critical building block for constructing novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by pharmaceutical chemists and process development scientists working in medicinal chemistry, particularly for the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Potential intermediate in the research and development of advanced crop protection agents due to its heterocyclic structure.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying enzyme function or cellular processes.

Basic Information

Item	Details
Product Name	Butanoic Acid, 2-[(2-Chloro-5-Nitro-4-Pyrimidinyl)Cyclopentylamino]-, Methyl Ester, (2R)-
CAS No.	755039-53-3
Molecular Formula	C15H19ClN4O4
Molecular Weight	354.79 g/mol
Synonyms	(2R)-Methyl 2-[(2-Chloro-5-nitro-4-pyrimidinyl)cyclopentylamino]butanoate; (R)-Methyl 2-((2-chloro-5-nitro-4-pyrimidinyl)cyclopentylamino)butanoate; Methyl (2R)-2-[(2-chloro-5-nitro-4-pyrimidinyl)cyclopentylamino]butanoate; 2-[(2-Chloro-5-nitro-4-pyrimidinyl)cyclopentylamino]butanoic acid methyl ester, (2R)-; CAS 755039-53-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D. Every batch is characterized and tested to ensure high chiral purity and chemical identity. Comprehensive analytical data, including HPLC for purity and chiral assay, is documented. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids and organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.