Description

Proline, 4-Hydroxy-, Methyl Ester, (4R)- (9Ci) is a high-purity, chiral proline derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of pharmaceuticals and bioactive compounds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the preparation of modified peptides and peptidomimetics to enhance stability and biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective transformations.
• Agrochemical Research: Employed in the development of novel, enantiomerically pure herbicides and plant growth regulators.
• Biochemical Research: Utilized as a standard or reagent in metabolic pathway studies and enzyme inhibition assays.
• Fine Chemical Synthesis: A versatile building block for creating complex natural products and specialty chemicals.

Basic Information

Product Name	Proline, 4-Hydroxy-, Methyl Ester, (4R)- (9Ci)
CAS No.	754962-86-2
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(4R)-4-Hydroxy-L-proline methyl ester; Methyl (4R)-4-hydroxypyrrolidine-2-carboxylate; L-4-Hydroxyproline methyl ester; (2S,4R)-4-Hydroxyproline methyl ester; 4(R)-Hydroxy-L-proline methyl ester; trans-4-Hydroxy-L-proline methyl ester; Hydroxyproline methyl ester
EINECS	Contact for details

Quality Control

Our Proline, 4-Hydroxy-, Methyl Ester, (4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.