Description

[4-(Difluoromethyl)Phenyl]Methanamine is a specialized aromatic amine building block featuring a difluoromethyl substituent, offering unique electronic and steric properties for advanced synthesis. This compound is valued for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the difluoromethyl group can significantly influence biological activity and metabolic stability. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances lipophilicity and target binding.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.
• Ligand and Catalyst Design: Utilized in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its aromatic amine functionality.

Basic Information

Product Name	[4-(Difluoromethyl)Phenyl]Methanamine
CAS No.	754920-30-4
Molecular Formula	C8H9F2N
Molecular Weight	157.16 g/mol
Synonyms	4-(Difluoromethyl)benzylamine; 1-[4-(Difluoromethyl)phenyl]methanamine; (4-(Difluoromethyl)phenyl)methanamine; α-(Difluoromethyl)benzylamine; p-(Difluoromethyl)benzylamine; 4-(Difluoromethyl)-benzenemethanamine; Benzenemethanamine, 4-(difluoromethyl)-; 4-Difluoromethylbenzylamine
EINECS	Contact for details

Quality Control

Our [4-(Difluoromethyl)Phenyl]Methanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to air, moisture, or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.