Description

Atopaxar CAS NO 751475-53-3 is a potent and selective protease-activated receptor 4 (PAR-4) antagonist. This compound is of significant interest for its potential role in modulating platelet aggregation and thrombosis, offering a novel mechanism of action for antiplatelet therapy. It is primarily utilized by pharmaceutical researchers and developers in the life sciences sector for preclinical and clinical research into cardiovascular diseases and novel anticoagulant treatments.

Application

• Pharmaceutical Research & Development: A key intermediate and reference standard in the discovery and development of novel antiplatelet and antithrombotic agents.
• Biochemical Research: Used as a selective tool compound in in vitro and in vivo studies to investigate PAR-4 receptor signaling pathways and platelet physiology.
• Clinical Trial Materials: Serves as a critical active pharmaceutical ingredient (API) or reference material in the manufacturing of formulations for clinical-stage studies.
• Mechanistic Studies: Employed to explore the differential roles of PAR-1 and PAR-4 in hemostasis and thrombosis, aiding in the understanding of cardiovascular pathologies.
• Academic Research: Utilized in university and institutional labs for fundamental research in pharmacology, hematology, and vascular biology.

Basic Information

Product Name	Atopaxar
CAS No.	751475-53-3
Molecular Formula	C23H23FN4O4S
Molecular Weight	470.51 g/mol
Synonyms	E5555; Atopaxar Hydrobromide (salt form); 1-(2-Methylpropyl)-N-[(2S)-3-[(methylsulfonyl)amino]-1-oxo-2-[[(phenylmethyl)amino]carbonyl]propyl]-1H-indazole-3-carboxamide; PAR-4 Antagonist E5555; 1-Isobutyl-N-[(2S)-3-[(methylsulfonyl)amino]-1-oxo-2-[[(phenylmethyl)amino]carbonyl]propyl]-1H-indazole-3-carboxamide
EINECS	Contact for details

Quality Control

Our Atopaxar is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.