Description

2-Chloro-4-(4-Methylpiperazin-1-Yl)Pyrimidine is a high-purity, advanced pharmaceutical intermediate with the CAS number 749898-92-8. This heterocyclic compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its precise chemical structure and reactivity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and commercial production of targeted kinase inhibitors and other small-molecule drugs.
• API Synthesis: Serves as a crucial precursor in multi-step synthetic routes for active pharmaceutical ingredients, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its pyrimidine core structure.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new heterocyclic chemistry and creating novel compound libraries.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke chemicals for client projects.

Basic Information

Product Name	2-Chloro-4-(4-Methylpiperazin-1-Yl)Pyrimidine
CAS No.	749898-92-8
Molecular Formula	C9H12ClN5
Molecular Weight	225.68 g/mol
Synonyms	2-Chloro-4-(4-methyl-1-piperazinyl)pyrimidine; 4-(4-Methylpiperazin-1-yl)-2-chloropyrimidine; 2-Chloro-4-(N-methylpiperazinyl)pyrimidine; 749898-92-8; 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine; 2-Chloro-4-(4-methyl-1-piperazinyl)-pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(4-Methylpiperazin-1-Yl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.