Description

H-Ala-Phe-Pro-βna · HCl is a synthetic peptide derivative, specifically a modified tripeptide amide, supplied as a hydrochloride salt. This compound is a valuable building block and intermediate in advanced pharmaceutical research and development, particularly in the design of protease inhibitors and bioactive peptide mimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel therapeutic peptides and peptidomimetics targeting various enzymes and receptors.
• Protease Inhibitor Research: Used in the development and screening of inhibitors for proteolytic enzymes, such as those involved in viral replication or inflammatory pathways.
• Medicinal Chemistry & SAR Studies: Employed as a core scaffold for structure-activity relationship (SAR) analysis to optimize drug potency, selectivity, and metabolic stability.
• Biochemical Tool Compound: Functions as a substrate or inhibitor in enzymatic assays to study protease kinetics and mechanism of action.
• Peptide Library Synthesis: A crucial component in the construction of combinatorial peptide libraries for high-throughput screening against biological targets.
• Academic & Contract Research: Supports fundamental research in biochemistry, molecular biology, and pharmacology within university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	H-Ala-Phe-Pro-βna · HCl
CAS No.	749831-27-4
Molecular Formula	C₂₀H₂₈N₄O₄ · HCl
Molecular Weight	425.92 g/mol (free base)
Synonyms	H-Ala-Phe-Pro-βna hydrochloride
Ala-Phe-Pro-βna · HCl
L-Alanyl-L-phenylalanyl-L-prolyl-2-naphthylamide hydrochloride
AFP-βna · HCl
Tripeptide amide derivative hydrochloride
N-(2-Naphthyl)-L-alanyl-L-phenylalanyl-L-prolinamide hydrochloride
Protease substrate analog hydrochloride
EINECS	Contact for details

Quality Control

Our H-Ala-Phe-Pro-βna · HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent tests for residual solvents and elemental impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with the rigorous standards required for pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.