Description

4,5,6-Trifluoroindoline-2,3-Dione is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical precursor for the development of novel pharmaceuticals and agrochemicals, where its unique trifluorinated indoline core imparts desirable metabolic stability and lipophilicity. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in developing new-generation herbicides and pesticides where fluorine atoms enhance biological activity and environmental persistence.
• Material Science: Serves as a building block for fluorinated organic electronic materials, such as semiconductors and OLED components.
• Chemical Biology: Employed as a probe or labeling agent due to the distinct properties conferred by the fluorine atoms.
• Academic & Contract Research: Utilized in universities and CROs for methodological studies in fluorination chemistry and heterocycle synthesis.

Basic Information

Product Name	4,5,6-Trifluoroindoline-2,3-Dione
CAS No.	749240-64-0
Molecular Formula	C8H2F3NO2
Molecular Weight	209.10 g/mol
Synonyms	4,5,6-Trifluoro-2,3-dihydro-1H-indole-2,3-dione; 4,5,6-Trifluoro-1H-indole-2,3-dione; 4,5,6-Trifluoroindole-2,3-dione; 4,5,6-Trifluoro-2,3-indolinedione; 4,5,6-Trifluoro-1H-indole-2,3(2H,3H)-dione; 4,5,6-Trifluoro-2,3-dioxoindoline; 4,5,6-Trifluoro-2,3-dihydroxyindole
EINECS	Contact for details

Quality Control

Our 4,5,6-Trifluoroindoline-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.