Description

4-Pyrimidinepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci) is a specialized fluorinated pyrimidine derivative, a high-value building block in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which incorporates both a reactive β-keto ester moiety and a fluorine atom, enabling precise structural modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex heterocyclic compounds. Its precise structure facilitates targeted molecular design in medicinal chemistry and material science applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides requiring fluorinated active components.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Research: Employed in academic and industrial R&D for exploring new fluorination reactions and heterocyclic chemistry.
• Material Science Precursor: Potential use in synthesizing specialty chemicals and functional materials with tailored properties.
• Custom Synthesis Building Block: Provides a critical fragment for contract research organizations (CROs) and CDMOs engaged in custom molecule fabrication.

Basic Information

Product Name	4-Pyrimidinepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci)
CAS No.	749216-36-2
Molecular Formula	C9H9FN2O3
Molecular Weight	212.18 g/mol
Synonyms	Ethyl 2-fluoro-3-oxo-3-(pyrimidin-4-yl)propanoate; 2-Fluoro-3-oxo-3-(4-pyrimidinyl)propanoic acid ethyl ester; 4-Pyrimidinepropanoic acid, 2-fluoro-3-oxo-, ethyl ester; Ethyl 2-fluoro-3-(4-pyrimidinyl)-3-oxopropanoate; α-Fluoro-β-oxo-4-pyrimidinepropanoic acid ethyl ester; 749216-36-2; 4-Pyrimidinepropionic acid derivative
EINECS	Contact for details

Quality Control

Our production of 4-Pyrimidinepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support our clients' regulatory needs with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.