Description

Methyl 5-Bromo-2-(tert-Butyl)Pyrimidine-4-Carboxylate is a high-purity, functionalized pyrimidine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators, leveraging its halogenated pyrimidine core.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a probe or labeling reagent in biochemical assays and proteomics research due to its reactive bromine and ester functional groups.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis and library production for drug discovery.

Basic Information

Product Name	Methyl 5-Bromo-2-(tert-Butyl)Pyrimidine-4-Carboxylate
CAS No.	746671-54-5
Molecular Formula	C10H13BrN2O2
Molecular Weight	273.13 g/mol
Synonyms	5-Bromo-2-tert-butylpyrimidine-4-carboxylic acid methyl ester; Methyl 5-bromo-2-(1,1-dimethylethyl)-4-pyrimidinecarboxylate; 4-Pyrimidinecarboxylic acid, 5-bromo-2-(1,1-dimethylethyl)-, methyl ester; 5-Bromo-2-tert-butyl-4-pyrimidinecarboxylic acid methyl ester; 746671-54-5; Methyl 5-bromo-2-(tert-butyl)pyrimidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-(tert-Butyl)Pyrimidine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.