Description

1H-Pyrazole-1-Sulfonamide, 4-(4-Amino-6-Quinazolinyl)-N,n-Dimethyl-3-(2-Pyridinyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of investigational drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• Biochemical Assay Development: Serves as a reference standard or probe molecule in high-throughput screening and enzyme inhibition assays.
• Academic & Contract Research: Utilized in university and CRO laboratories for cutting-edge research in chemical biology and drug discovery.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1H-Pyrazole-1-Sulfonamide, 4-(4-Amino-6-Quinazolinyl)-N,n-Dimethyl-3-(2-Pyridinyl)-
CAS No.	746669-24-9
Molecular Formula	C₁₈H₁₉N₇O₂S
Molecular Weight	397.46 g/mol
Synonyms	4-(4-Amino-6-quinazolinyl)-N,N-dimethyl-3-(2-pyridinyl)-1H-pyrazole-1-sulfonamide; 4-(4-Amino-quinazolin-6-yl)-N,N-dimethyl-3-pyridin-2-yl-1H-pyrazole-1-sulfonamide; 746669-24-9; 1H-Pyrazole-1-sulfonamide, 4-(4-amino-6-quinazolinyl)-N,N-dimethyl-3-(2-pyridinyl)-; N,N-Dimethyl-4-(4-amino-6-quinazolinyl)-3-(2-pyridinyl)-1H-pyrazole-1-sulfonamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and traceability. Every lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality management systems and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.