Description

n-Boc-2,6-Difluoroaniline is a high-purity, protected aniline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine group, enabling selective reactions in complex multi-step sequences, particularly for the development of active pharmaceutical ingredients (APIs). This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules, especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoroaniline moiety imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, dyes, and liquid crystals, leveraging the electronic effects of fluorine atoms.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	n-Boc-2,6-Difluoroaniline
CAS No.	745833-17-4
Molecular Formula	C11H13F2NO2
Molecular Weight	229.22 g/mol
Synonyms	tert-Butyl (2,6-difluorophenyl)carbamate; 2,6-Difluoroaniline, N-BOC-protected; N-(tert-Butoxycarbonyl)-2,6-difluoroaniline; Boc-2,6-F2-aniline; 1,3-Difluoro-2-((tert-butoxycarbonyl)amino)benzene; N-Boc-2,6-difluoro-benzenamine; (2,6-Difluorophenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-2,6-Difluoroaniline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring material traceability and data integrity under cGMP and ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.