Description

L-Proline, 4-Methyl-, Ethyl Ester, cis- (9Ci) is a high-purity, non-natural amino acid derivative, specifically an esterified form of a methyl-substituted proline. This compound is a critical chiral building block and intermediate in modern organic synthesis, offering precise stereochemical control for complex molecule construction. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide mimetics and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained, methylated proline analogs, influencing peptide secondary structure and stability.
• Medicinal Chemistry Research: Serves as a valuable scaffold for constructing focused libraries in drug discovery programs targeting various disease pathways.
• Asymmetric Synthesis: Acts as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Agrochemical Synthesis: Potential intermediate in the synthesis of advanced, biologically active compounds for crop protection.

Basic Information

Product Name	L-Proline, 4-Methyl-, Ethyl Ester, cis- (9Ci)
CAS No.	745769-71-5
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	(2S,4S)-4-Methylpyrrolidine-2-carboxylic acid ethyl ester; cis-4-Methyl-L-proline ethyl ester; Ethyl (2S,4S)-4-methylpyrrolidine-2-carboxylate; L-4-Methylproline ethyl ester; (2S,4S)-Ethyl 4-methylpyrrolidine-2-carboxylate; 4-Methyl-L-proline ethyl ester; cis-4-Methylproline ethyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Methyl-, Ethyl Ester, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.