Description

2-Piperazin-1-Yl-5-(Trifluoromethyl)Pyrimidine is a high-value, heterocyclic building block featuring a pyrimidine core substituted with a piperazine ring and a trifluoromethyl group. This unique structure makes it a critical intermediate in modern pharmaceutical research and development, particularly for the synthesis of targeted small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other bioactive molecules.
• Agrochemical Research: Used in the synthesis of novel active ingredients for crop protection products.
• Chemical Biology: Serves as a versatile scaffold for constructing molecular probes and tool compounds.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Material Science: Potential precursor for specialty chemicals and advanced functional materials.

Basic Information

Product Name	2-Piperazin-1-Yl-5-(Trifluoromethyl)Pyrimidine
CAS No.	745066-18-6
Molecular Formula	C9H10F3N5
Molecular Weight	245.21 g/mol
Synonyms	5-(Trifluoromethyl)-2-(1-piperazinyl)pyrimidine; 2-(Piperazin-1-yl)-5-(trifluoromethyl)pyrimidine; 1-(5-(Trifluoromethyl)pyrimidin-2-yl)piperazine; 745066-18-6; 2-Piperazin-1-yl-5-trifluoromethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Piperazin-1-Yl-5-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.