Description

4H-Cyclopenta[G]Quinazolin-4-One, 2-Amino-1,6,7,8-Tetrahydro- is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring quinazolinone structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a scaffold for constructing compound libraries in high-throughput screening (HTS) for identifying new lead structures.
• Oncology Drug Development: Its quinazolinone core is a privileged structure in designing molecules that interfere with specific cancer cell pathways.
• CNS-Active Compound Synthesis: Employed in research programs aimed at developing treatments for neurological disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university laboratories for studying heterocyclic chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	4H-Cyclopenta[G]Quinazolin-4-One, 2-Amino-1,6,7,8-Tetrahydro-
CAS No.	743420-65-7
Molecular Formula	C₁₁H₁₁N₃O
Molecular Weight	201.23 g/mol
Synonyms	2-Amino-1,6,7,8-tetrahydro-4H-cyclopenta[g]quinazolin-4-one; 2-Amino-1,2,3,4-tetrahydro-4H-cyclopenta[g]quinazolin-4-one; 743420-65-7; 2-Amino-4-oxo-1,4,6,7,8,8a-hexahydrocyclopenta[g]quinazoline; Tetrahydrocyclopenta[g]quinazolinone derivative; ATCQ; Advanced Tetrahydroquinazolinone Intermediate
EINECS	Contact for details

Quality Control

Every batch of 4H-Cyclopenta[G]Quinazolin-4-One, 2-Amino-1,6,7,8-Tetrahydro- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.