Description

Ethanone, 1-(3,4-Dihydro-1(2H)-Quinolinyl)-2-(Thieno[2,3-D]Pyrimidin-4-Yloxy)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new drug candidates, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates and investigational new drugs (INDs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Employed in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies due to its thienopyrimidine moiety.
• CNS-Active Compound Synthesis: Utilized in creating compounds for neurological disorder research, leveraging its quinoline-derived structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects under cGMP conditions.
• Biochemical Tool Compound: Acts as a reference standard or a probe molecule in biochemical and pharmacological assays.

Basic Information

Item	Detail
Product Name	Ethanone, 1-(3,4-Dihydro-1(2H)-Quinolinyl)-2-(Thieno[2,3-D]Pyrimidin-4-Yloxy)-
CAS No.	742113-71-9
Molecular Formula	C₁₉H₁₇N₃O₂S
Molecular Weight	351.42 g/mol
Synonyms	1-(1,2,3,4-Tetrahydroquinolin-1-yl)-2-(thieno[2,3-d]pyrimidin-4-yloxy)ethanone; 2-(Thieno[2,3-d]pyrimidin-4-yloxy)-1-(3,4-dihydro-2H-quinolin-1-yl)ethan-1-one; 1-(3,4-Dihydroquinolin-1(2H)-yl)-2-(thieno[2,3-d]pyrimidin-4-yloxy)ethanone; Quinoline-thienopyrimidine ketone derivative; CAS 742113-71-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and traceability. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Quality assurance is aligned with ISO 9001 standards, and we can support development projects requiring materials manufactured under cGMP guidelines for preclinical and clinical stage use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.