Description

2-Trifluoromethyl-5,6,7,8-Tetrahydro-Pyrido[4,3-D]Pyrimidin-4-Ol is a high-purity, heterocyclic organic compound featuring a fused pyrido-pyrimidine core substituted with a trifluoromethyl group. This advanced pharmaceutical intermediate is valued for its unique structural motif, which is critical for imparting desirable metabolic stability and bioavailability in drug candidates. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• As a key building block in medicinal chemistry for the development of kinase inhibitors and other targeted therapeutics.
• Utilized in pharmaceutical R&D for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders.
• Serves as a versatile scaffold in combinatorial chemistry and high-throughput screening libraries.
• Employed in agrochemical research for creating novel compounds with herbicidal or pesticidal activity.
• Used as a reference standard in analytical method development and quality control laboratories.
• Acts as a precursor for further chemical modifications to explore structure-activity relationships (SAR).

Basic Information

Product Name	2-Trifluoromethyl-5,6,7,8-Tetrahydro-Pyrido[4,3-D]Pyrimidin-4-Ol
CAS No.	741737-19-9
Molecular Formula	C9H10F3N3O
Molecular Weight	233.19 g/mol
Synonyms	4-Hydroxy-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol; 741737-19-9; 4-Pyrimidinol, 5,6,7,8-tetrahydro-2-(trifluoromethyl)pyrido[4,3-d]-; 2-Trifluoromethyl-5,6,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidin-4-one (tautomer); TFMPP Intermediate; Pyrido[4,3-d]pyrimidine derivative.
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-5,6,7,8-Tetrahydro-Pyrido[4,3-D]Pyrimidin-4-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider keeping the container under an inert atmosphere in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.