Description

2-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Isoindoline-1,3-Dione is a high-purity heterocyclic organic compound featuring a fused pyrrolopyrimidine and isoindoline-1,3-dione (phthalimide) structure. This unique molecular architecture makes it a critical advanced intermediate for pharmaceutical research and development, particularly in the synthesis of targeted kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Biochemical Research: Used as a core scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex drug candidates targeting specific enzymatic pathways.
• Life Science Reagents: Employed in the development of biochemical probes and assay tools for high-throughput screening and target validation.
• Custom Synthesis: Provides a versatile starting point for contract research organizations (CROs) and CDMOs developing proprietary compounds for clients.

Basic Information

Product Name	2-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Isoindoline-1,3-Dione
CAS No.	741686-49-7
Molecular Formula	C14H8N4O2
Molecular Weight	264.24 g/mol
Synonyms	4-(1,3-Dioxoisoindolin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine; 2-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)isoindoline-1,3-dione; 1H-Pyrrolo[2,3-d]pyrimidine, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-7H-; 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine; 741686-49-7; Pyrrolo[2,3-d]pyrimidine-4(7H)-yl-phthalimide derivative
EINECS	Contact for details

Quality Control

Our 2-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Isoindoline-1,3-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.