Description

D-Histidine, n-Methyl- (9Ci) is a specialized, non-proteinogenic amino acid derivative characterized by its methylated imidazole side chain. This compound is of significant value in advanced pharmaceutical research and development, particularly for its role as a key chiral building block and a potential precursor for novel bioactive molecules. It is primarily required by research institutions and pharmaceutical companies engaged in peptide synthesis, medicinal chemistry, and the development of diagnostic agents or enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry Research: Used to incorporate modified histidine residues into synthetic peptides to study structure-activity relationships and modulate biological properties.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies, particularly those involving histidine-related metabolic pathways.
• Diagnostic Agent Development: Potential precursor for radiolabeled compounds or contrast agents used in medical imaging.
• Asymmetric Synthesis: Employed as a building block in catalytic and stoichiometric asymmetric synthesis due to its defined stereochemistry.

Basic Information

Product Name	D-Histidine, n-Methyl- (9Ci)
CAS No.	738564-96-0
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	D-N-Methylhistidine; (R)-1-Methyl-1H-imidazole-4-alanine; (2R)-2-Amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid; D-1-Methylhistidine; D-π-Methylhistidine; Methyl-D-histidine; (R)-N-Methylhistidine; D-N(π)-Methylhistidine
EINECS	Contact for details

Quality Control

Our D-Histidine, n-Methyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.