Description

2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine is a high-value heterocyclic building block characterized by its tetrahydropyrido[3,4-d]pyrimidine core and a strategically positioned trifluoromethyl group. This compound is essential for medicinal chemistry and pharmaceutical research, where it serves as a privileged scaffold for developing novel small molecule therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for lead optimization and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors, receptor antagonists, and other targeted therapeutic agents.
• Medicinal Chemistry Scaffold: Used extensively in lead optimization and library synthesis for drug discovery programs due to its drug-like properties and ability to modulate pharmacokinetics.
• Agrochemical Research: Employed in the synthesis of novel active ingredients for crop protection products, leveraging the bioactivity of the pyrimidine core.
• Chemical Biology Probe: Serves as a core structure for developing molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a building block for advanced organic electronic materials and ligands in catalysis.

Basic Information

Product Name	2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine
CAS No.	737754-25-5
Molecular Formula	C9H8F3N3
Molecular Weight	215.18 g/mol
Synonyms	5,6,7,8-Tetrahydro-2-(trifluoromethyl)pyrido[3,4-d]pyrimidine; 2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; Pyrido[3,4-d]pyrimidine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)-; 737754-25-5; 2-Trifluoromethyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.