Description

Pyrrolo[1,2-C]Pyrimidine-4-Carboxylic Acid, 1-Amino-4A,5,6,7-Tetrahydro-3- is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and the development of new synthetic methodologies.
• Bioconjugation & Probe Development: The amino and carboxylic acid functional groups make it suitable for conjugation chemistry in developing diagnostic probes or targeted drug delivery systems.

Basic Information

Product Name	Pyrrolo[1,2-C]Pyrimidine-4-Carboxylic Acid, 1-Amino-4A,5,6,7-Tetrahydro-3-
CAS No.	737737-01-8
Molecular Formula	C9H11N3O2
Molecular Weight	193.20 g/mol
Synonyms	1-Amino-4a,5,6,7-tetrahydro-3H-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid; 1-Amino-4a,5,6,7-tetrahydro-3H-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid; 737737-01-8; Pyrrolo[1,2-c]pyrimidine-4-carboxylic acid, 1-amino-4a,5,6,7-tetrahydro-3-; 4a,5,6,7-Tetrahydro-1H-pyrrolo[1,2-c]pyrimidine-1-amine-4-carboxylic acid; 1-Amino-4a,5,6,7-tetrahydro-3H-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid (non-preferred tautomer); Pyrrolopyrimidine carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity (HPLC), identity (IR, NMR), and impurity profiles. We support development from non-GMP research quantities through to cGMP-compliant production for clinical trial material, with documentation tailored to meet regulatory submission requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.