Description

Fmoc-L-7-Azatrp CAS NO 737007-45-3 is a protected derivative of the non-proteinogenic amino acid 7-azatryptophan, featuring the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the α-amino function. This specialized building block is critical for the solid-phase peptide synthesis (SPPS) of peptides containing the unique 7-azaindole side chain, which can impart specific photophysical or biochemical properties. It is an essential reagent for researchers and manufacturers in pharmaceutical R&D and biotechnology, enabling the exploration of novel peptide-based therapeutics and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental building block for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used to incorporate the 7-azatryptophan moiety into peptide drug candidates to study structure-activity relationships, enhance stability, or introduce fluorescence properties.
• Biochemical Probe Development: The 7-azaindole side chain serves as a versatile fluorescent label or spectroscopic handle for studying protein-protein interactions and enzyme mechanisms.
• Peptide Library Construction: Enables the creation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Academic Research: Employed in university and institutional labs for fundamental studies in peptide chemistry, bioconjugation, and chemical biology.
• Bioconjugation: The synthesized peptides can be further modified and conjugated to other molecules, surfaces, or carriers for diagnostic or therapeutic applications.

Basic Information

Product Name	Fmoc-L-7-Azatrp
CAS No.	737007-45-3
Molecular Formula	C₂₇H₂₃N₃O₄
Molecular Weight	453.49 g/mol
Synonyms	Fmoc-7-aza-L-tryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-aza-L-tryptophan; Fmoc-L-7-azatryptophan; Fmoc-7-azatrp-OH; Nα-Fmoc-7-azatryptophan; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid; Fmoc-AzaTrp-OH; Fmoc-7-Azatryptophan
EINECS	Contact for details

Quality Control

Our Fmoc-L-7-Azatrp is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and chiral analysis to confirm enantiomeric integrity. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.