Description

2-Chloro-4-(1-Ethoxyvinyl)-5-Fluoropyrimidine is a high-purity fluorinated pyrimidine derivative, a crucial building block in advanced organic synthesis. Its molecular architecture makes it an indispensable intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer research. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty fine chemical industries for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel nucleoside analogs and other bioactive molecules targeting viral and oncological diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging the pyrimidine core's biological activity.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds to study enzyme function and cellular pathways.
• Material Science Precursor: Potential intermediate for the synthesis of specialty polymers and liquid crystals with unique electronic properties.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis facilities for client-directed projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in fluorination and cross-coupling reactions.

Basic Information

Product Name	2-Chloro-4-(1-Ethoxyvinyl)-5-Fluoropyrimidine
CAS No.	736991-75-6
Molecular Formula	C8H8ClFN2O
Molecular Weight	202.61 g/mol
Synonyms	5-Fluoro-2-chloro-4-(1-ethoxyvinyl)pyrimidine; 2-Chloro-5-fluoro-4-(1-ethoxyethenyl)pyrimidine; 4-(1-Ethoxyvinyl)-2-chloro-5-fluoropyrimidine; 736991-75-6; 2-Chloro-4-(1-ethoxyvinyl)-5-fluoropyrimidine; 5-Fluoropyrimidine, 2-chloro-4-(1-ethoxyvinyl)-; 2-Chloro-5-fluoro-4-vinyloxypyrimidine (related structure)
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(1-Ethoxyvinyl)-5-Fluoropyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.