Description

2(1H)-Pyrimidinone,4-Amino-5-Bromo-5,6-Dihydro-6-Hydroxy-1-Methyl-,trans-(9Ci) is a high-purity, specialized pyrimidinone derivative serving as a critical building block in advanced organic synthesis. Its unique brominated and amino-hydroxylated structure makes it an invaluable intermediate for pharmaceutical research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists working in oncology, antiviral, and other therapeutic areas requiring complex heterocyclic scaffolds.

Application

This brominated pyrimidinone derivative is a versatile synthetic intermediate with primary applications in advanced chemical manufacturing.

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and antiviral research programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of API synthesis routes.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms and biological pathways.
• Agrochemical Research: Potential intermediate in the discovery of new herbicides or fungicides with novel modes of action.
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in heterocyclic chemistry and reaction methodology.

Basic Information

Product Name	2(1H)-Pyrimidinone,4-Amino-5-Bromo-5,6-Dihydro-6-Hydroxy-1-Methyl-,trans-(9Ci)
CAS No.	734489-50-0
Molecular Formula	C5H8BrN3O2
Molecular Weight	222.04 g/mol
Synonyms	trans-4-Amino-5-bromo-5,6-dihydro-6-hydroxy-1-methyl-2(1H)-pyrimidinone; 4-Amino-5-bromo-5,6-dihydro-6-hydroxy-1-methylpyrimidin-2(1H)-one; 5-Bromo-5,6-dihydro-6-hydroxy-1-methyl-4-pyrimidinamine; 734489-50-0; (trans)-4-Amino-5-bromo-5,6-dihydro-6-hydroxy-1-methyl-2(1H)-pyrimidinone; 4-Amino-5-bromo-5,6-dihydro-6-hydroxy-1-methyl-2(1H)-pyrimidinone (trans); 1-Methyl-4-amino-5-bromo-5,6-dihydro-6-hydroxy-2-pyrimidinone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and purity. Material is characterized and released according to comprehensive in-house specifications, which typically include identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support development and commercial projects with quality documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.