Description

7-Chloro-2-Chloromethyl-1H-Quinazolin-4-One is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a critical precursor for developing novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the creation of complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need this intermediate for synthesizing potential therapeutic agents, particularly in oncology and CNS drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel quinazoline-based kinase inhibitors and other targeted small molecule drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides with specific modes of action.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential building block for specialty polymers and organic electronic materials requiring specific heterocyclic components.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Item	Detail
Product Name	7-Chloro-2-Chloromethyl-1H-Quinazolin-4-One
CAS No.	730951-40-3
Molecular Formula	C9H6Cl2N2O
Molecular Weight	229.06 g/mol
Synonyms	7-Chloro-2-(chloromethyl)-4(1H)-quinazolinone; 2-Chloromethyl-7-chloro-1H-quinazolin-4-one; 7-Chloro-2-chloromethylquinazolin-4(1H)-one; 4(1H)-Quinazolinone, 7-chloro-2-(chloromethyl)-; 730951-40-3; Quinazolin-4-one derivative
EINECS	Contact for details

Quality Control

Our 7-Chloro-2-Chloromethyl-1H-Quinazolin-4-One is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting all specifications is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.