Description

4-(2,4-Difluorophenyl)Benzaldehyde is a high-purity aromatic aldehyde building block featuring a difluorinated phenyl substituent. This compound is valued for its role as a versatile synthetic intermediate in advanced organic synthesis, where its aldehyde group and fluorinated aromatic ring enable precise molecular construction. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules. The compound, with CAS number 728918-75-0, is supplied to meet the stringent demands of modern chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic semiconductors, charge-transport materials, and liquid crystal compounds used in display technologies.
• Cross-Coupling Reactions: The aldehyde functionality makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Ligand & Catalyst Development: Employed in the preparation of specialized fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer & Resin Modifier: Incorporated as a monomer or additive to impart specific thermal, optical, or solubility properties to high-performance polymers.

Basic Information

Product Name	4-(2,4-Difluorophenyl)Benzaldehyde
CAS No.	728918-75-0
Molecular Formula	C13H8F2O
Molecular Weight	218.20 g/mol
Synonyms	4-(2,4-Difluorophenyl)benzaldehyde; [1,1'-Biphenyl]-4-carboxaldehyde, 2',4'-difluoro-; 2',4'-Difluoro[1,1'-biphenyl]-4-carboxaldehyde; 4-(2,4-Difluorophenyl)benzenecarbaldehyde; (2,4-Difluorophenyl)benzaldehyde; 4-Formyl-2',4'-difluorobiphenyl
EINECS	Contact for details

Quality Control

Our 4-(2,4-Difluorophenyl)Benzaldehyde is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.