Description

Benzenamine, 2-(Difluoromethyl)-4-Methoxy- (9Ci) is a specialized aromatic amine derivative featuring a difluoromethyl substituent. This compound is valued as a key synthetic intermediate in advanced organic synthesis, particularly for introducing fluorinated motifs into target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients. Its unique structure makes it a critical building block for compounds requiring specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Material Science Research: Employed in the development of advanced polymers and liquid crystals, where its aromatic amine core can act as a monomer or modifying agent.
• Organic Light-Emitting Diode (OLED) Materials: Investigated as a precursor for electron-transporting or host materials in OLED device fabrication.
• Fluorinated Compound Library Synthesis: A valuable reagent for medicinal chemistry and chemical biology labs building diverse screening libraries to explore structure-activity relationships (SAR).
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed cross-coupling reactions, such as Buchwald-Hartwig amination, for constructing complex nitrogen-containing heterocycles.

Basic Information

Product Name	Benzenamine, 2-(Difluoromethyl)-4-Methoxy- (9Ci)
CAS No.	727993-36-4
Molecular Formula	C8H9F2NO
Molecular Weight	173.16 g/mol
Synonyms	2-(Difluoromethyl)-4-methoxyaniline; 4-Methoxy-2-(difluoromethyl)aniline; 2-(Difluoromethyl)-4-methoxybenzenamine; Aniline, 2-(difluoromethyl)-4-methoxy-; 2-Amino-5-methoxybenzylidene difluoride; 4-Methoxy-α,α-difluoro-o-toluidine; 2-(Difluoromethyl)-4-methoxyphenylamine
EINECS	Contact for details

Quality Control

Our Benzenamine, 2-(Difluoromethyl)-4-Methoxy- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.