Description

2-(4-Fluoro-Phenylamino)-2-Methyl-Propionic Acid is a specialized fluorinated amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique structure, which incorporates both a fluorine atom and a sterically hindered amino acid moiety, enabling precise modifications in target molecules. It is primarily required by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the fluorine substituent can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the design of chiral ligands and organocatalysts for asymmetric synthesis, leveraging its steric and electronic properties.
• Peptidomimetics Research: Serves as a non-natural amino acid analog in the design of peptide-like molecules with improved metabolic stability and binding affinity.
• Material Science Precursor: Acts as a functional monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties.
• Chemical Biology Probe: Utilized as a building block for creating molecular probes to study enzyme mechanisms and protein interactions.

Basic Information

Item	Details
Product Name	2-(4-Fluoro-Phenylamino)-2-Methyl-Propionic Acid
CAS No.	725234-46-8
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	2-[(4-Fluorophenyl)amino]-2-methylpropanoic acid; 2-Methyl-2-[(4-fluorophenyl)amino]propanoic acid; α-Methyl-4-fluoroanilinoisobutyric acid; 4-Fluoro-α-methylanilinoisobutyric acid; 2-(4-Fluoroanilino)-2-methylpropionic acid; 2-(p-Fluoroanilino)isobutyric acid; 725234-46-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Fluoro-Phenylamino)-2-Methyl-Propionic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity research and development requirements, with specifications typically exceeding 97% purity by HPLC. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment. We support development projects with custom synthesis and purification services to meet specific project specifications, including pharmaceutical development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.