Description

1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Hydroxy-7-[(4As,7As)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel fluoroquinolone antibiotics, offering a pathway to develop next-generation antimicrobial agents. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of new antibacterial drugs targeting resistant pathogens.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of advanced fluoroquinolone antibiotic active pharmaceutical ingredients (APIs).
• Antibacterial Drug Research: Used in medicinal chemistry for the research and development of new antibacterial compounds with improved efficacy and safety profiles.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of antibiotic drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) of quinolone-based antimicrobials.

Basic Information

Product Name	1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Hydroxy-7-[(4As,7As)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	721970-36-1
Molecular Formula	C20H22FN3O4
Molecular Weight	387.41 g/mol
Synonyms	7-[(4aS,7aS)-Octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic acid; (4aS,7aS)-7-(Octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid; GSK-2140944 Intermediate; Novel Quinolone Antibacterial Intermediate; 1-Cyclopropyl-6-fluoro-8-hydroxy-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Hydroxy-7-[(4As,7As)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-3-Quinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance with cGMP and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.