Description

2-Pyrimidinecarboxylicacid,4-Ethylhexahydro-,(2R,4S)-Rel-(9Ci) is a high-purity, stereochemically defined heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in its role as a key chiral intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise, high-quality intermediates for asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Research: Used in the development of new, stereoselective pesticides and herbicides where specific chirality impacts biological activity.
• Asymmetric Catalyst Ligand Synthesis: Acts as a precursor for creating sophisticated chiral ligands used in transition metal catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic & Institutional R&D: A valuable reagent for methodological studies in organic chemistry, particularly in exploring new stereoselective transformations.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for commercial production of chiral molecules.

Basic Information

Product Name	2-Pyrimidinecarboxylicacid,4-Ethylhexahydro-,(2R,4S)-Rel-(9Ci)
CAS No.	721447-93-4
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	(2R,4S)-rel-4-Ethylhexahydro-2-pyrimidinecarboxylic acid; 4-Ethylhexahydro-2-pyrimidinecarboxylic acid, (2R,4S)-rel-; Hexahydro-4-ethyl-2-pyrimidinecarboxylic acid (relative stereochemistry); 721447-93-4; 4-Ethyl-1,4,5,6-tetrahydropyrimidine-2-carboxylic acid (specified stereoisomer); Chiral tetrahydropyrimidine-2-carboxylic acid derivative; Ethyl-substituted hexahydropyrimidine carboxylate.
EINECS	Contact for details

Quality Control

Every batch of our 2-Pyrimidinecarboxylicacid,4-Ethylhexahydro-,(2R,4S)-Rel-(9Ci) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. Our standard quality commitment includes rigorous testing by HPLC, chiral HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at 2-8°C in a cool, dry, and well-ventilated place. The compound may be hygroscopic; containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.