Description

Tetrabenazine is a high-purity, synthetically produced vesicular monoamine transporter 2 (VMAT2) inhibitor used as a critical active pharmaceutical ingredient (API). Its primary value lies in its specific neurological activity, making it essential for the formulation of treatments for hyperkinetic movement disorders. This compound is vital for pharmaceutical manufacturers and research institutions focused on developing and producing advanced neurological therapeutics and conducting related pharmacological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for chorea associated with Huntington's disease.
• Neurological Research: A key reference standard and tool compound in preclinical studies investigating monoamine transport and movement disorder mechanisms.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of tetrabenazine-based drugs.
• Metabolite Studies: Used in the synthesis and analysis of its major active metabolites (e.g., α-dihydrotetrabenazine) for pharmacokinetic profiling.
• Formulation Development: Serves as the core component in the R&D of new dosage forms, such as optimized tablets or controlled-release formulations.

Basic Information

Product Name	Tetrabenazine
CAS No.	718635-93-9
Molecular Formula	C19H27NO3
Molecular Weight	317.42 g/mol
Synonyms	Nitoman; Ro 1-9569; TBZ; 1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one; (3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one; Xenazine; Deutetrabenazine Intermediate
EINECS	Contact for details

Quality Control

Our Tetrabenazine is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, assay, and impurity profiling via HPLC and related pharmacopeial methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.