Description

Ethyl 5-Methyl-7-(Trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate is a high-value, fluorinated pyrazolopyrimidine derivative, a crucial advanced intermediate in modern pharmaceutical synthesis. Its molecular architecture, featuring a tetrahydropyrimidine core and a trifluoromethyl group, makes it indispensable for creating novel bioactive compounds with enhanced metabolic stability and membrane permeability. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged scaffold.
• Kinase Inhibitor Development: A critical precursor in the synthesis of potential kinase inhibitors, a major class of therapeutics for cancer and inflammatory diseases.
• Agrochemical Research: Employed in the discovery of new active ingredients for crop protection, leveraging the bioactivity of the pyrazolopyrimidine core.
• Chemical Biology Probes: Utilized to create tool compounds for studying specific biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.

Basic Information

Product Name	Ethyl 5-Methyl-7-(Trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS No.	712319-10-3
Molecular Formula	C12H14F3N3O2
Molecular Weight	289.25 g/mol
Synonyms	Ethyl 5-methyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate; 5-Methyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid ethyl ester; 712319-10-3; Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 4,5,6,7-tetrahydro-5-methyl-7-(trifluoromethyl)-, ethyl ester; Ethyl 5-methyl-7-(trifluoromethyl)-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development and commercial projects with material produced under quality agreements and can supply material suitable for use in GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.