Description

7-(Difluoromethyl)-5-(4-Fluorophenyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is a high-value, multi-fluorinated heterocyclic building block. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially for oncology and inflammatory diseases.
• Kinase Inhibitor Scaffold: Serves as a core structural motif for designing and synthesizing potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged pyrazolopyrimidine core.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.
• Agrochemical Research: Potential application in the discovery of new active ingredients, leveraging its fluorinated heterocyclic structure.

Basic Information

Product Name	7-(Difluoromethyl)-5-(4-Fluorophenyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid
CAS No.	712319-09-0
Molecular Formula	C15H9F3N3O2
Molecular Weight	328.25 g/mol
Synonyms	7-(Difluoromethyl)-5-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 5-(4-Fluorophenyl)-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 7-(difluoromethyl)-5-(4-fluorophenyl)-; 712319-09-0; 7-Difluoromethyl-5-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 7-(Difluoromethyl)-5-(4-Fluorophenyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.