Description

Vorapaxar Sulfate is a high-purity, non-peptide protease-activated receptor-1 (PAR-1) antagonist. This compound is of significant interest for its potent and selective antiplatelet activity, making it a critical intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery and advanced pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of the active pharmaceutical ingredient (API) for antiplatelet medications.
• Reference Standard: Used for quality control, method validation, and calibration in analytical laboratories (HPLC, LC-MS).
• Biomedical Research: A vital tool for studying PAR-1 receptor signaling pathways, platelet aggregation mechanisms, and thrombosis.
• Preclinical Development: Employed in pharmacological and toxicological studies to evaluate efficacy and safety profiles of novel antithrombotic agents.
• Formulation Research: Used in the development and testing of various drug delivery systems for cardiovascular therapeutics.

Basic Information

Product Name	Vorapaxar Sulfate
CAS No.	705260-08-8
Molecular Formula	C29H33FN2O4 · H2SO4
Molecular Weight	590.65 g/mol (free base: 492.58)
Synonyms	SCH 530348 Sulfate; Vorapaxar hydrogen sulfate; (1R,3aR,4aR,9bS)-6-(3-Fluorophenyl)-1,2,3a,4,4a,5,9b,10-octahydro-1,4a-epoxybenzo[3,4]cyclobuta[1,2-c]azepin-8-yl]methylcarbamate sulfate; Zontivity (Brand Name) Intermediate; PAR-1 Antagonist; Antiplatelet Agent Intermediate
EINECS	Contact for details

Quality Control

Our Vorapaxar Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.