Description

Fmoc-Ser(Allyl)-Oh is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically designed to introduce a serine residue with a protected side-chain hydroxyl group, allowing for selective deprotection and further functionalization during complex peptide assembly. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled construction of peptide chains.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Labeling: The allyl-protected side chain allows for orthogonal deprotection, facilitating site-specific conjugation with fluorescent dyes, polymers, or other bioactive molecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds and lead optimization.
• Glycopeptide Synthesis: Serves as a precursor for the synthesis of O-glycosylated serine residues, important for studying glycoprotein function.
• Chemical Biology Research: A vital tool for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways using synthetic peptide probes.

Basic Information

Product Name	Fmoc-Ser(Allyl)-Oh
CAS No.	704910-17-8
Molecular Formula	C₂₁H₂₁NO₅
Molecular Weight	367.40 g/mol
Synonyms	Fmoc-Ser(All)-OH; Fmoc-O-allyl-L-serine; N-(9-Fluorenylmethoxycarbonyl)-O-allyl-L-serine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(prop-2-en-1-yloxy)propanoic acid; Fmoc-L-serine(allyl) ether; Fmoc-Ser(Allyl)-OH; Fmoc-Ser(OAllyl)-OH; Fmoc-Ser(O-All)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Allyl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure the material meets the stringent requirements for advanced peptide synthesis and cGMP-compatible applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.