Description

n-Methyl-D-Proline Hydrochloride is a high-purity, non-natural amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound is valued for its role in modulating the conformational and pharmacological properties of peptide-based therapeutics and other bioactive molecules. It is essential for research and development laboratories and production facilities in the pharmaceutical and biotechnology sectors, particularly for creating novel drug candidates with improved stability and target specificity. The product is supplied under stringent quality control to ensure batch-to-batch consistency for demanding applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptidomimetics and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used to introduce constrained, N-alkylated proline analogs into peptide chains to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a building block in structure-activity relationship (SAR) studies and the development of protease inhibitors or receptor ligands.
• Asymmetric Synthesis: Employed as a chiral auxiliary or catalyst component in stereoselective chemical transformations.
• Bioconjugation: Potential use in the design of linker molecules for antibody-drug conjugates (ADCs) and other targeted therapies.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	n-Methyl-D-Proline Hydrochloride
CAS No.	702710-17-6
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62 g/mol
Synonyms	(2R)-1-Methylpyrrolidine-2-carboxylic acid hydrochloride; D-1-Methylproline hydrochloride; (R)-1-Methylproline hydrochloride; D-N-Methylproline HCl; (R)-N-Methylproline hydrochloride; Methyl-D-proline HCl; 1-Methyl-D-proline hydrochloride; (2R)-1-Methyl-2-pyrrolidinecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our n-Methyl-D-Proline Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We can support development with specifications aligned with ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.