Description

4-Phenyl-6-Trifluoromethyl-Pyrimidine-2-Thiol is a high-value, multi-functional heterocyclic building block characterized by its phenyl and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the CF3 group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the bioactivity of the pyrimidine-thiol core.
• Material Science Research: Serves as a precursor for organic electronic materials and ligands in catalytic systems.
• Chemical Biology: Employed as a building block for probes and inhibitors in biochemical assay development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	4-Phenyl-6-Trifluoromethyl-Pyrimidine-2-Thiol
CAS No.	701920-69-6
Molecular Formula	C11H7F3N2S
Molecular Weight	256.25 g/mol
Synonyms	6-(Trifluoromethyl)-4-phenylpyrimidine-2-thiol; 4-Phenyl-6-(trifluoromethyl)-2-pyrimidinethiol; 2-Mercapto-4-phenyl-6-(trifluoromethyl)pyrimidine; 4-Phenyl-6-trifluoromethyl-2-mercaptopyrimidine; 2-Pyrimidinethiol, 4-phenyl-6-(trifluoromethyl)-; 701920-69-6; 4-Phenyl-6-trifluoromethylpyrimidine-2-thiol
EINECS	Contact for details

Quality Control

Every batch of 4-Phenyl-6-Trifluoromethyl-Pyrimidine-2-Thiol is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); it is recommended to handle and store under an inert atmosphere such as nitrogen or argon for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.