Description

2-Amino-9-[(1S,3R,4S)-4-(Dimethylphenylsilyl)-3-(Hydroxymethyl)-2-Methylenecyclopentyl]-1,9-Dihydro-6H-Purin-6-One is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. This compound matters for its role as a sophisticated building block in the synthesis of novel nucleoside analogues and antiviral agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of next-generation therapeutics targeting viral infections and other diseases.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of experimental antiviral and anticancer nucleoside drugs.
• Antiviral Drug Research: Serves as a key scaffold for developing novel protease inhibitors and polymerase inhibitors for viral targets.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Prodrug Synthesis: The functional groups allow for conjugation to targeting moieties or conversion into prodrug forms to enhance bioavailability.
• Academic Research: Utilized in universities and research institutes for studying enzyme mechanisms and nucleotide metabolism.

Basic Information

Product Name	2-Amino-9-[(1S,3R,4S)-4-(Dimethylphenylsilyl)-3-(Hydroxymethyl)-2-Methylenecyclopentyl]-1,9-Dihydro-6H-Purin-6-One
CAS No.	701278-07-1
Molecular Formula	C₂₀H₂₅N₅O₂Si
Molecular Weight	395.54 g/mol
Synonyms	2-Amino-9-[(1S,3R,4S)-4-(dimethylphenylsilyl)-3-(hydroxymethyl)-2-methylenecyclopentyl]-9H-purin-6-one; (1S,3R,4S)-4-(Dimethylphenylsilyl)-3-(hydroxymethyl)-2-methylenecyclopentyl 6-oxopurine derivative; 2-Amino-9-(4-(dimethyl(phenyl)silyl)-3-(hydroxymethyl)-2-methylidenecyclopentyl)-1H-purin-6-one; Advanced Nucleoside Intermediate; Silylated Cyclopentyl Purine Derivative; Antiviral Nucleoside Precursor; CAS 701278-07-1
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality control protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under GMP-grade conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is between -20°C to -10°C. For short-term use, allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.