Description

cis-4-[4-(4-Amino-7,7-Dimethyl-7H-Pyrimido[4,5-B][1,4]Oxazin-6-Yl)Phenyl]Cyclohexaneacetic Acid CAS NO 701234-65-3 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel therapeutic agents, particularly in oncology and targeted drug discovery. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing next-generation small molecule drugs and kinase inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of targeted cancer therapies and kinase inhibitors.
• Biochemical Research: Used in academic and industrial research for studying enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Drug Discovery & Development: A key scaffold for medicinal chemists in hit-to-lead optimization and the development of novel active pharmaceutical ingredients (APIs).
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects under cGMP conditions.
• Reference Standard: Utilized as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	cis-4-[4-(4-Amino-7,7-Dimethyl-7H-Pyrimido[4,5-B][1,4]Oxazin-6-Yl)Phenyl]Cyclohexaneacetic Acid
CAS No.	701234-65-3
Molecular Formula	C22H26N4O3
Molecular Weight	394.47 g/mol
Synonyms	cis-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid; 4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid (cis-isomer); 701234-65-3; cis-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexaneacetic acid; (1r,4r)-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexane-1-acetic acid; (1s,4s)-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexane-1-acetic acid; cis-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexylacetic acid
EINECS	Contact for details

Quality Control

Our cis-4-[4-(4-Amino-7,7-Dimethyl-7H-Pyrimido[4,5-B][1,4]Oxazin-6-Yl)Phenyl]Cyclohexaneacetic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and analytical methods are provided with each batch and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.