Description

4-Chloro-2-(4-Methylpiperazin-1-yl)pyrimidine is a high-purity, synthetically valuable heterocyclic building block. This compound matters as a critical intermediate in the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under cGMP conditions.
• Chemical Biology Probes: Utilized in the creation of tool compounds for target validation and pathway analysis.
• Custom Synthesis: Foundation for the preparation of more complex, functionalized pyrimidine derivatives for specialized applications.

Basic Information

Product Name	4-Chloro-2-(4-Methylpiperazin-1-yl)pyrimidine
CAS No.	700803-93-6
Molecular Formula	C9H12ClN5
Molecular Weight	225.68 g/mol
Synonyms	4-Chloro-2-(4-methyl-1-piperazinyl)pyrimidine; 2-(4-Methylpiperazin-1-yl)-4-chloropyrimidine; 4-Chloro-2-(4-methylpiperazin-1-yl)pyrimidine; 700803-93-6; 4-Chloro-2-(N-methylpiperazinyl)pyrimidine; 4-Chloro-2-(4-methylpiperazino)pyrimidine; 4-Chloro-2-(4-methyl-1,4-diazepan-1-yl)pyrimidine (tautomer); 4-Chloro-2-(4-methylpiperazin-1-yl)-pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(4-Methylpiperazin-1-yl)pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.