Description

Fmoc-L-β-Homoarginine(Pmc) CAS NO 700377-76-0 is a protected, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over arginine-like side chain functionality during solid-phase peptide assembly. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic laboratories focused on developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of homoarginine analogs into peptide chains, enabling the study of structure-activity relationships.
• Pharmaceutical Research: Used in the development of peptide-based drug candidates targeting cardiovascular, neurological, and metabolic disorders where arginine-like motifs are essential.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or affinity tags for proteomics and diagnostic assay development.
• Enzyme Substrate & Inhibitor Design: Employed to synthesize specific substrates or inhibitors for enzymes like trypsin-like proteases that recognize arginine residues.
• Chemical Biology Studies: Facilitates the exploration of protein-protein interactions and signal transduction pathways by incorporating modified arginine analogs into bioactive peptides.

Basic Information

Product Name	Fmoc-L-β-Homoarginine(Pmc)
CAS No.	700377-76-0
Molecular Formula	C34H41N5O7S
Molecular Weight	663.79 g/mol
Synonyms	Fmoc-β-hArg(Pmc)-OH; N-α-Fmoc-N-ω-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-homoarginine; Fmoc-L-homoarginine(Pmc)-OH; Fmoc-Homoarginine(Pmc); NG-(Pmc)-Nα-Fmoc-L-homoarginine; (2S)-5-[[(2,2,5,7,8-Pentamethyl-3,4-dihydro-2H-1-benzopyran-6-yl)sulfonyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; Boc-L-Homoarginine(Pmc)-OH analog; Protected L-Homoarginine derivative
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homoarginine(Pmc) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.