Description

Dynorphin A (1-11) Amide is a bioactive peptide fragment derived from the endogenous opioid peptide Dynorphin A. This compound is a critical research tool for investigating the kappa opioid receptor (KOR) system, which plays a significant role in pain modulation, stress response, and neurological disorders. It is primarily utilized by researchers and developers in the fields of neuroscience, pharmacology, and drug discovery for receptor binding studies, signal transduction research, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective ligand for studying the structure, function, and distribution of kappa opioid receptors (KOR) in the central nervous system.
• Pharmacological Studies: Used in in vitro and in vivo assays to investigate pain pathways, stress responses, and the mechanisms of addiction and reward.
• Drug Discovery & Development: Serves as a reference standard and a starting point for the design and screening of new analgesic or neuroprotective compounds targeting the KOR.
• Biochemical Assays: Employed in competitive binding assays and functional studies (e.g., GTPγS binding) to characterize receptor affinity and efficacy.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on neuropeptides, opioid systems, and behavioral pharmacology.

Basic Information

Product Name	Dynorphin A (1-11) Amide
CAS No.	79985-48-1
Molecular Formula	C61H92N18O14
Molecular Weight	1301.5 g/mol
Synonyms	Dynorphin A (1-11)-NH2; [Des-Tyr1]-Dynorphin A (2-11) amide; Dynorphin A 1-11 amide; Dynorphin A (1-11)NH2; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-NH2; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-NH2; Leu-Enkephalin, Arg6,7, Ile8, Arg9, Pro10, Lys11-amide
EINECS	Contact for details

Quality Control

Our Dynorphin A (1-11) Amide is manufactured under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, and other critical parameters are provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.